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Sacks J. "2009 Final Report: Integrated Science Assessment for Particulate Matter". The ensuing air pollution is characterized by raised sulfur dioxide and nitrogen oxide levels and really high concentrations of airborne particles and particulate matter (PM). Some cities in Northern China and South Asia have had concentrations above 200 μg/m3. Newer scientific studies have shown that some pollutants can harm public health and welfare even at very low levels.
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Pyridine (1) is lowered with sodium borohydride in presence of benzyl chloroformate to the Cbz protected dihydropyridine 2. The asymmetric Diels-Alder reaction with acrolein 3 is carried out with the McMillan catalyst to the aldehyde 4 because the endo isomer which is oxidized to the carboxylic acid 5 with sodium chlorite, monopotassium phosphate and 2-methyl-2-butene. Addition of bromine provides halolactonization product 6 and after replacement of the Cbz protective group by a BOC protecting group in 7 (hydrogenolysis within the presence of di-tert-butyl dicarbonate) a carbonyl group is introduced in intermediate eight by catalytic ruthenium(IV) oxide and sacrificial catalyst sodium periodate.